N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester
Boc-Asp-OtBu
CAS: 34582-32-6
Molecular Formula: C13H23NO6
N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester - Names and Identifiers
N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C13H23NO6 |
| Molar Mass | 289.32 |
| Density | 1.139 |
| Melting Point | 101-103?C |
| Boling Point | 429.0±40.0 °C(Predicted) |
| Flash Point | 213.3°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.46E-08mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| BRN | 4191701 |
| pKa | 4.13±0.19(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.47 |
N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2924 19 00 |
N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester - Introduction
Boc-Asp-OtBu, commonly known as Boc-Asp-OtBu, is an organic compound. The following is an introduction to some of its properties, uses, formulation and safety information:
Nature:
-Appearance: Colorless crystalline or powdery objects.
-Molecular formula: C≡H≡NO-7.
-Molecular weight: 393.47g/mol.
-Melting point: about 68-70°C.
-Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane (DCM).
Use:
- Boc-Asp-OtBu is a commonly used protecting group, often used in the synthesis of peptides and protein compounds. It can protect the carboxyl and amino groups of glutamic acid (Asp) and prevent accidental reactions and degradation.
- Boc-Asp-OtBu can also be used as reaction intermediates in organic synthesis, such as in peptide synthesis and drug synthesis.
Preparation Method:
-Usually, Boc-Asp-OtBu is prepared by reacting the corresponding amino acid (L-glutamic acid) with a tert-butyl protecting group (Boc) and a tert-butoxycarbonyl protecting group (OtBu). The reaction is carried out under suitable conditions, for example by addition of an activator such as 1-(trimethylsilyl)-1H-pyrazol-3-one (TBTU) or N,N'-diisopropylmethylamide (DIPCDI) in an organic solvent.
Safety Information:
- Boc-Asp-OtBu with low toxicity.
-Because it is an organic compound, avoid inhaling dust or contact with skin and eyes.
-When operating, you need to follow appropriate laboratory safety measures, such as wearing protective gloves and eye protection.
-When storing, it should be kept in a cool, dry place, and away from fire and oxidizing agents.
The above content is for reference only, please follow the correct chemical experiment operation specifications when using and handling the Boc-Asp-OtBu.
Nature:
-Appearance: Colorless crystalline or powdery objects.
-Molecular formula: C≡H≡NO-7.
-Molecular weight: 393.47g/mol.
-Melting point: about 68-70°C.
-Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane (DCM).
Use:
- Boc-Asp-OtBu is a commonly used protecting group, often used in the synthesis of peptides and protein compounds. It can protect the carboxyl and amino groups of glutamic acid (Asp) and prevent accidental reactions and degradation.
- Boc-Asp-OtBu can also be used as reaction intermediates in organic synthesis, such as in peptide synthesis and drug synthesis.
Preparation Method:
-Usually, Boc-Asp-OtBu is prepared by reacting the corresponding amino acid (L-glutamic acid) with a tert-butyl protecting group (Boc) and a tert-butoxycarbonyl protecting group (OtBu). The reaction is carried out under suitable conditions, for example by addition of an activator such as 1-(trimethylsilyl)-1H-pyrazol-3-one (TBTU) or N,N'-diisopropylmethylamide (DIPCDI) in an organic solvent.
Safety Information:
- Boc-Asp-OtBu with low toxicity.
-Because it is an organic compound, avoid inhaling dust or contact with skin and eyes.
-When operating, you need to follow appropriate laboratory safety measures, such as wearing protective gloves and eye protection.
-When storing, it should be kept in a cool, dry place, and away from fire and oxidizing agents.
The above content is for reference only, please follow the correct chemical experiment operation specifications when using and handling the Boc-Asp-OtBu.
Last Update：2024-04-09 21:04:16
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View History
N-(tert-Butoxycarbonyl)-L-aspartic acid 1-tert-butyl ester
tert-butyl (5-methyl-3-nitro-1H-pyrazol-1-yl)acetate
NSC 254051
1-异丙烯基-4-甲氧基苯
Tamsulosin Impurity 32
tert-butyl (5-methyl-3-nitro-1H-pyrazol-1-yl)acetate
NSC 254051
1-异丙烯基-4-甲氧基苯
Tamsulosin Impurity 32